The Red Devils are unbeaten in 10 matches in all competitions ahead of their trip to Linzer Stadion, where they will take on LASK for the first time ever in a competitive match.
Due to the spread of the coronavirus across Europe, it was announced on Tuesday that this game will now be played behind closed doors.
Not only have both players fitted into the squad seamlessly, particularly in the case of regular starter Fernandes, but they have also managed to improve the performances of those around them.
The Red Devils have won seven matches in their ongoing 10-game unbeaten run, most recently seeing off bitter rivals Manchester City 2-0 on Sunday.
That will be enough for Champions League qualification should City's two-year European ban be upheld, but Solskjaer's men also have another route into UEFA's showpiece competition.
For that to happen they will have to match their achievement of 2017 by going all the way in the Europa League.
After easing through the group stage and brushing aside Club Brugge 6-1 on aggregate in the first knockout round, United are now the bookies' favourite to win the competition.
Taking that successful run three years ago into account, the Red Devils have lost just one of their last 19 matches in the Europa League, winning 13 of those.
LASK are the side tasked with halting United's recent revival, and they also enter this fixture full of confidence after opening up a six-point lead at the top of the Austrian Bundesliga.
On the continent, meanwhile, the Black-Whites are unbeaten in their last six matches, beating the likes of PSV Eindhoven and AZ already in this season's competition.
LASK Linz's Europa League form: DWWWDW
LASK Linz's form (all competitions): DWWWLW
Manchester United's Europa League form: WWLWDW
Manchester United's form (all competitions): DWWDWW
LASK may be unknown opposition in many ways but United fan favourite Fernandes know them well, having scored and assisted against the Austrian outfit for Sporting Lisbon during the group stage.
No team has had more different goalscorers in the Europa League this season than United, with Fred, Fernandes and McTominay all on the scoresheet in the win over Brugge last month.
LASK Linz possible starting lineup:
Schlager; Trauner, Ramsebner, Wostry; Ranflt, Holland, Michorl, Renner; Frieser, Goiginger; Raguz
Manchester United possible starting lineup:
Romero; Wan-Bissaka, Bailly, Maguire, Shaw; Fred, Matic, McTominay; Fernandes; Martial, Ighalo
We say: LASK Linz 0-2 Manchester United
United have won seven and drawn one of their eight previous encounters with Austrian sides. The Red Devils enter this match on a fine run of form and we are backing them to take a commanding lead into next week's return fixture at Old Trafford.