The midweek derby win over Manchester United was seen by many as City's last major hurdle to overcome, but Pep Guardiola's side cannot afford to let up yet and know that anything other than all three points at Turf Moor could hand the advantage back to Liverpool.
Indeed, Man City could still start Sunday's match second in the table should Liverpool avoid a major upset at home to Huddersfield Town on Friday night, despite the champions having won their last 11 league games.
Here, Sports Mole looks at how Guardiola could set his team out as they look to make it 12 in a row.
With Kevin De Bruyne already sidelined, Man City picked up two more midfield injury concerns during the derby when both Fernandinho and Ilkay Gundogan came off with knocks.
Guardiola has not taken any risks with Fernandinho in recent weeks and is unlikely to do so this weekend as the Brazilian struggles with a knee problem, but Gundogan's "kick on his leg" is less serious and Fernandinho's expected absence increases the importance of the German playing.
Fernandinho's withdrawal at Old Trafford actually set the wheels in motion for Man City to go on and win the game, and Bernardo Silva could start in the deeper midfield position from which he scored in midweek.
Leroy Sane was the man to replace Fernandinho and may have earned a starting role with his goal, particularly considering Bernardo dropping back would free up a place in the front three alongside Sergio Aguero and Raheem Sterling.