It was City's fifth missed penalty in their last seven attempts in all competitions.
The omens were perhaps bad when City lost to Wolves on penalties in the Premier League Asia Trophy in China in pre-season. Ilkay Gundogan, David Silva and Lukas Nmecha all had efforts saved in a shoot-out in Shanghai, after Raheem Sterling had missed one in normal time.
They did win a Community Shield shoot-out against Liverpool but here, the PA news agency looks at their mixed record since.
Sergio Aguero (4 penalties, 3 goals)
City's record goalscorer has had his problems from the spot in the past – notably missing in last season's Champions League loss to Spurs – and he had a 100 per cent record this term, until Saturday. The Argentinian began the season with a spot-kick in the 5-0 win at West Ham on the opening day – albeit having been spared by VAR after an initial miss – and also netted against Watford in the Premier League and Atalanta in the Champions League. However, Schmeichel's save ended the run of successes.
Ilkay Gundogan (3 penalties, 2 goals)
City turned to the German and with good results until he missed at Tottenham earlier this month. With Aguero not on the field, Gundogan scored against Leicester in December and Fulham in the FA Cup last week. He kept the job at Spurs even with Aguero on the field, but Hugo Lloris saved from the former Borussia Dortmund midfielder.
Gabriel Jesus (2 penalties, 0 goals)
The Brazilian was the choice when City were awarded a penalty against Atalanta at the San Siro in November but his weak effort dribbled tamely wide. Things got no better when he missed a penalty for Brazil a week later. He had a chance to restore his confidence at Sheffield United last month but Dean Henderson saved.
Raheem Sterling (1 penalty, 0 goals)
The England forward was the man who stepped up at Wolves in December but Rui Patricio, the man who thwarted him in pre-season, twice denied him – from a first attempt and from a retake. Sterling was alert enough to score from the rebound from the retake, but it still counts as a miss.
City manager Pep Guardiola may decide to keep faith with Aguero – with no obvious contender to replace him.
Riyad Mahrez's last penalty attempt was blazed well over the bar at Liverpool in October 2018 and even Kevin De Bruyne has suffered in the past, being denied by Everton's Maarten Stekelenburg in 2016.
Bernardo Silva could be an option but a left-field choice would be goalkeeper Ederson. Guardiola recently described the Brazilian as the best penalty-taker in the squad – practical reasons have prevented him being tried so far but they may eventually think it worth the risk.