Cardiff too have plenty to play for and are still within touching distance of the playoffs, but a run of one win in five matches has left them on the back foot.
Bottom of the Championship and seven points adrift of safety, a run of eight defeats in 10 Championship fixtures has given Luton it all to do if they wish to stay up.
Luton's home form has been far better than their away form this term, with 18 of their 24 points and five of their seven wins coming at Kenilworth Road.
In fact, the Hatters have taken 10 points from their last six home games and will need to build on that if they are to have any hope of staying up.
Neil Harris's side are now seven points adrift of the playoffs, but have picked up just two wins on the road all season.
With the 18th-worst away record in the league, this is an area they will need to find significant improvement if they are to return to the Premier League at the first time of asking.
Cardiff have been good in attack this season with 42 goals, but are conceding far more often than in previous seasons.
With 31 goals conceded in just 15 away matches, Luton should look to take advantage of this vulnerability in Cardiff's game.
However, if results elsewhere go their way, Harris's team could find themselves eighth if they secure a win.
Luton Town Championship form: LLLLWL
Luton Town form (all competitions): LLLLWL
Cardiff City Championship form: WLDDWD
Cardiff City form (all competitions): WDDWDL
Cardiff will still be without dangerous winger Nathaniel Mendez-Laing, who will not be seen this season due to a hamstring injury.
There also doubts over Matthew Connolly, who is being assessed day to day following an ankle injury he picked up early last month.
Luton Town possible starting lineup:
Sluga; Bree, Pearson, Daniels, Potts; Tunnicliffe, Rea, Mpanzu; Cornick, Collins, LuaLua
Cardiff City possible starting lineup:
Smithies, Richards, Morrison, Nelson, Bennett; Vaulks, Pack, Bacuna, Tomlin; Paterson, Glatzel
We say: Luton Town 0-1 Cardiff City
Cardiff have not been in the best form of late, but with the playoffs still a distinct possibility they should have just about enough to see off this struggling Luton side.
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