Jurgen Klopp's men - who were also knocked out of the FA Cup by Manchester United - have now slipped to fourth in the table and could find themselves seven points behind Manchester City if they beat West Bromwich Albion on Tuesday.
Here, Sports Mole looks at how Liverpool could line up for Thursday's game.
Liverpool have now gone four games without a goal in the top flight - their worst drought for over 20 years - so Klopp will be desperate to have his attackers firing on all cylinders at the Tottenham Hotspur Stadium this week.
Mohamed Salah managed to bag a brace at Old Trafford, while Roberto Firmino got the winner against Spurs earlier in the season, so there is certainly cause for optimism as the Reds' famed attacking trio lines up on Thursday.
The middle of the park is where the questions lie, as Klopp's inspirational captain Jordan Henderson is 50-50 for this one due to a reported groin problem which kept him out against Burnley and Man United.
Should the England international indeed miss out once again, Thiago and Georginio Wijnaldum could be partnered by Alex Oxlade-Chamberlain as Klopp goes all out to break down a dogged Tottenham defence.
James Milner is another option for the visitors with Naby Keita also injured, and the former RB Leipzig man is joined on the sidelines by long-term absentees Diogo Jota, Virgil van Dijk and Joe Gomez.
The majority of Liverpool's rearguard is set to remain untouched, but Joel Matip - who has experienced his fair share of injury problems as well - should replace Rhys Williams alongside makeshift centre-back Fabinho.
Watch the Sports Mole Football Shorts prediction for this game below: