Although the home side are safely in mid-table, they head into the contest at Stadio Olimpico on the back of six games without success.
While Simone Inzaghi has received widespread praise for the job he has done with Lazio this season, the former striker must now come through a period of criticism in order to end the campaign on a high.
Four defeats from five games, which includes a defeat at leaders Juventus, have left Lazio in fourth position, 11 points adrift of the defending champions.
Fortunately for I Biancocelesti, rivals Roma sit the same distance behind them in fifth place, putting them under no threat of losing the final Champions League spot.
Nevertheless, with second position still a realistic possibility, there will be a desire to get another victory on the board as soon as possible.
Although Inzaghi will expect at least one win to come from home fixtures with Thursday's opponents or Brescia, Lazio have netted just two goals from open play in their last five encounters.
Like their hosts, Cagliari are becoming increasing desperate to end a prolonged period without a maximum return, a run which stretches back to June 27.
However, four of their last six outings have ended in draws, including against in-form Sassuolo on Saturday evening in a game where they played at a man disadvantage from the 48th minute.
Despite being presented with arguably the toughest run-in of all the 20 teams in the division, it may suit a group of players who still have ambitions of ending the campaign in the top half of the table.
Lazio Serie A form: WLLLDL
Cagliari Serie A form: DLDDLD
Luis Alberto is one of a number of Lazio players who remain absent through injury, something which led to Inzaghi being unable to fill his substitutes' bench for the last match.
Although Patric is back in contention after a ban, Inzaghi may be prepared to name the same starting lineup.
The dismissal of Carboni against Sassuolo will lead to Zenga making at least one alteration for the trip to Rome.
The return of the Argentine would probably result in Gaston Pereiro having to be content with a spot on the substitutes' bench.
Lazio possible starting lineup:
Strakosha; Bastos, Felipe, Acerbi; Lazzari, Milinkovic-Savic, Cataldi, Parolo, Anderson; Caicedo, Immobile
Cagliari possible starting lineup:
Cragno; Cepptelli, Pisacane, Klavan; Nandez, Farago, Rog, Birsa, Mattiello; Simeone, Pedro
We say: Lazio 2-0 Cagliari
Despite their recent dismal run, we feel that this is the perfect fixture for Lazio to get back on track. Although Cagliari may make things difficult for a time, the home side should be able to come through with a relatively comfortable win.