The Bianconeri wrapped up top spot with two games to spare and can now afford to switch focus to next month's Champions League last-16 second leg against Lyon.
Here, Sports Mole looks at how the champions could line up against Cagliari at the Sardegna Arena.
The extent of Dybala's thigh injury is unknown, but he seems certain to miss Juve's remaining two league games of the season.
The same is true for Danilo, who was lucky to escape any serious damage after suffering a nasty head injury at the weekend.
To make matters worse for Sarri, Douglas Costa's campaign may also be over after damaging his thigh in training last week.
Even without those injuries to contend with, changes can be expected on Wednesday as Sarri looks to freshen things up with an eye on the rearranged Lyon tie.