Juve have won an unprecedented eight Scudettos in a row and have taken 16 points from the 18 available at the start of this season, but they still have to play second fiddle to Sunday's hosts.
Inter Milan have won six from six domestically so far and look well placed to seriously challenge Juve's dominance under Antonio Conte, who led the Old Lady to the first three titles in their incredible run.
Here, Sports Mole looks at how Juventus could line up for the contest.
The bulk of Juventus' injury concerns come in defence, with Giorgio Chiellini a long-term absentee and Mattia De Sciglio and Danilo both still sidelined for this match.
The injuries to the latter two mean that Juan Cuadrado has been forced to fill in as an emergency right-back in recent games, a role the former Chelsea winger could once again fulfil this weekend.
Maurizio Sarri is still able to call upon a solid defensive duo of Matthijs de Ligt and Leonardo Bonucci, though, and they could be coming up against a weakened Inter attack with Alexis Sanchez suspended and Romelu Lukaku an injury doubt.
Injuries at the back have also resulted in a change from Sarri's usual 4-3-3 formation further forward, with the Italian having gone for more of a 4-4-2 diamond in recent matches.body check tags ::