Antonio Conte's side were given an extra week to recover due to their involvement in the Europa League final, but Fiorentina opened their league season last weekend with a 1-0 win over Torino.
Inter's 2019-20 campaign might have ended in disappointment as they lost to Sevilla in the Europa League final, but there is no question that the Italian side made huge strides forward last term.
Indeed, Conte's team finished second in Serie A, just a single point behind the champions Juventus, and the club's supporters will be expecting another title challenge this season.
It seems incredible to think that Inter have not won Serie A since 2010, while they finished ninth in 2012-13 and eighth in 2014-15 during a very difficult period.
Back-to-back fourth-place finishes were followed by second last term, though, and the Black and Blues have put together a squad full of quality and one certainly capable of again challenging for silverware this term.
Achraf Hakimi has been the club's major incoming this summer in terms of a transfer fee, while Lautaro Martinez is also still at the club despite suggestions that Barcelona are determined to sign him.
Fiorentina, meanwhile, opened their 2020-21 Serie A campaign with a 1-0 victory over Torino last weekend courtesy of a 78th-minute strike from Gaetano Castrovilli.
The Purple One improved on their 16th-place finish in 2018-19 to claim 10th last season but are still some way off being the top-four side that they were between 2012 and 2015.
A quick glance at the Fiorentina squad suggests that they have the quality to push for a top-half finish this season, though, and Giuseppe Iachini's side have actually now won their last three league matches.
La Viola are also unbeaten in each of their last three Serie A matches with Inter, including a goalless draw in the corresponding fixture between the two sides in the latter stages of last season.
Inter Milan pre-season form: WW
Fiorentina Serie A form: W
Fiorentina, meanwhile, have no fresh concerns from their win over Torino last weekend, meaning that Iachini could select the same XI that took to the field against Torino.
Federico Chiesa has been linked with a move away from the club this summer, but it seems likely that the Italian will stick around, and he could again feature on the right at San Siro.
Inter Milan possible starting lineup:
Handanovic; D'Ambrosio, Bastoni, Kolarov; Hakimi, Barella, Gagliardini, Perisic; Eriksen; Lukaku, Martinez
Fiorentina possible starting lineup:
Dragowski; Milenkovic, Ceccherini, Caceres; Chiesa, Bonaventura, Duncan, Castrovilli, Biraghi; Ribery, Kouame
We say: Inter Milan 2-0 Fiorentina
Fiorentina will have been boosted by their win on the opening weekend of the season, but Inter are the strong favourites to triumph on Saturday. The hosts might not be at full strength, but we fully expect Conte's side to start their 2020-21 campaign with a positive result.