The home side started their league season with a 3-2 victory at Stuttgart last weekend, while Wolfsburg opened with a goalless draw against Bayer Leverkusen.
Freiburg finished eighth in the Bundesliga last season, which represented their best position since 2016-17 and followed placings of 15th and 13th in 2017-18 and 2018-19 respectively.
Breisgau-Brasilianer have spent £9m on French midfielder Baptiste Santamaria, though, and there could be more business at the club before the transfer window closes at the start of October.
Wolfsburg, meanwhile, started their 2020-21 Bundesliga campaign with a goalless draw at home to Leverkusen last weekend, which will have to go down as a positive result.
The German side have also twice been in action in the qualifying rounds of this season's Europa League, beating Kukesi and Desna to set up a playoff clash with AEK Athens next Wednesday.
Die Wolfe finished seventh in the Bundesliga last season and will be desperate to qualify for the group stages of Europe's second competition, which would give their finances a huge boost during a difficult period.
The club's summer business has been modest in terms of incomings and outgoings, although they did receive more than £6m by selling central defender Felix Uduokhai to Augsburg.
Freiburg Bundesliga form: W
Freiburg form (all competitions): WW
Wolfsburg Bundesliga form: D
Wolfsburg form (all competitions): WWDW
Freiburg will again be without the services of Mark Flekken due to an elbow injury, while Keven Schlotterbeck and Janik Haberer are likely to miss out for the home side with muscular and ankle issues respectively.
New signing Santamaria was not involved on the opening weekend of the season but should feature here.
There are unlikely to be many changes from the side that started against Stuttgart, though, with Petersen, Sallai and Grifo all expected to keep their attacking roles alongside Lucas Holer.
The importance of Thursday's Europa League clash with Desna meant that head coach Oliver Glasner had to select a strong side, and there is expected to be a familiar look to the XI on Sunday.
Wout Weghorst has been linked with a move to Tottenham Hotspur this summer, but the Dutchman remains at the club for the moment and should lead the line with support from Joao Victor and Josip Brekalo.
Freiburg possible starting lineup:
Muller; Schmid, Lienhart, Heintz, Gunter; Santamaria; Sallai, Jeong, Grifo; Petersen, Holer
Wolfsburg possible starting lineup:
Casteels; Steffen, Lacroix, Brooks, Roussillon; Schlager, Arnold, Mehmedi, Victor, Weghorst, Brekalo
We say: Freiburg 1-1 Wolfsburg
Both managers would likely accept a draw if it were offered ahead of kickoff, and we are struggling to separate the two teams here. There is not an awful lot between them in terms of quality, while they played out a 2-2 draw in their last meeting in the Bundesliga in the middle of June.