Didier Deschamps's side recorded a 1-0 win over Sweden in their tournament opener last time out, while Croatia suffered a heavy 4-1 loss to holders Portugal to drop to the bottom of the section.
France were far from their best against Sweden on Saturday night, but a first-half goal from Kylian Mbappe ensured that the world champions would collect all three points in Solna.
Les Bleus picked up seven points from their four matches against the Netherlands and Germany in the 2018-19 UEFA Nations League but failed to advance as they finished second in the section.
Deschamps's side breezed through their Euro 2020 qualification campaign, though, winning eight of their 10 matches, picking up 25 points to finish at the summit, and there is no question that the 2018 World Cup winners will be amongst the favourites to triumph in next summer's tournament.
A victory against Croatia on Tuesday night would lead France nicely into next month's home game against Portugal, who will also fancy their chances of topping this particular section.
As mentioned, Croatia opened their 2020-21 campaign with a 4-1 defeat to Portugal on Saturday night, which means that there is more pressure on them to pick up a result in this match.
It is a big ask for Vatreni to top this section, but a positive result against France would put them in a decent position ahead of their next game in the group at home to Sweden on October 11.
Like Les Bleus, Croatia will also be present at next summer's European Championships, having finished top of Group E, picking up 17 points from their eight matches during a strong qualification campaign.
Zlatko Dalic's side have now won just one of their five UEFA Nations League games, though, having failed to make an impression in the 2018-19 edition, finishing bottom of League A Group 4.
Croatia and France famously last locked horns in the 2018 World Cup final, with Deschamps's side running out 4-2 winners in Moscow to lift the trophy for the second time.
France Nations League form: DWWLW
France form (all competitions): WWDWWW
Croatia Nations League form: LDWLL
Croatia form (all competitions): DWDWWL
France will be without the services of Mbappe for Tuesday's contest as the Paris Saint-Germain attacker has been forced to withdraw from the squad after testing positive for coronavirus.
Mbappe immediately left the national team upon receiving the news and his absence could open the door for Manchester United attacker Anthony Martial to start in the final third of the field.
Deschamps said ahead of the clash with Sweden that he wanted to "work on several tactical schemes" before the Euros, and the world champions lined up in a 3-4-1-2 formation in Solna.
Paul Pogba and Tanguy Ndombele were both forced to withdraw from the France squad ahead of the Sweden match after testing positive for coronavirus, meaning that Adrien Rabiot could again be given the chance to make his mark in midfield alongside N'Golo Kante.
France possible starting lineup:
Lloris; Upamecano, Varane, Lenglet; Dubois, Kante, Rabiot, Mendy; Griezmann; Martial, Ben Yedder
Croatia possible starting lineup:
Livakovic; Jedvaj, Lovren, Vida, Barisic; Kovacic, Brozovic; Rebic, Vlasic, Perisic; Kramaric
We say: France 2-0 Croatia
A full-strength Croatia are certainly capable of upsetting France, but the visitors will again be missing some key players for this contest. France were not at their best against Sweden last time out; the world champions came through the contest with three points, though, and we fancy them to secure another victory here.