There was to be no fairytale ending for Wayne Rooney in his reunion with Manchester United on Thursday, as Luke Shaw's opener and a brace from Odion Ighalo sent Ole Gunnar Solskjaer's side through to the last eight of the FA Cup at the expense of Cocu's side.
The Rams must now focus purely on the league and will be looking to build upon their 3-1 win over Sheffield Wednesday at Hillsborough last week.
Derby will welcome Blackburn to a ground where they have only lost twice all season in the Championship, and Cocu's men can boast the third-best home record in the league with nine wins, seven draws and two defeats.
The Rams could go as high as 10th in the table with a five-goal victory over the former Premier League champions, but they would have to hope that Wednesday, Cardiff City and Millwall all lose their respective matches.
Tony Mowbray's side are only three points off sixth-placed Preston North End, however, and are unbeaten in their last four Championship matches away from home.
Furthermore, Rovers have not failed to score on their travels since they suffered a 1-0 defeat to Birmingham City back in October, and their +10 goal difference is the best in the league outside the top six.
Should Preston and Bristol City both fail to pick up wins this weekend, Blackburn would climb into the playoff places with victory at Pride Park.
Derby County Championship form: WLDDLW
Derby County form (all competitions): LDDLWL
Blackburn Rovers Championship form: LWWDDD
Cocu is expected to make changes to the side that lost to United in midweek.
Tom Lawrence limped off in the FA Cup defeat, while Andre Wisdom missed out through illness. Both are being assessed ahead of the weekend's fixture.
Bradley Johnson may be rewarded for his last-minute heroics against Swansea with a spot in the starting XI, and Danny Graham could also be recalled.
Derby County possible starting lineup:
Hamer; Bogle, Clarke, Davies, Forsyth; Bird, Shinnie, Waghorn, Rooney, Knight; Martin
Blackburn Rovers possible starting lineup:
Walton; Bennett, Nyambe, Adarabioyo, Bell; Travis, Johnson, Gallagher, Armstrong, Downing; Graham
We say: Derby County 2-2 Blackburn Rovers
Derby have been impressive at Pride Park all season, and Blackburn haven't been able to stop scoring away from home in the past few months. With that in mind, we are going for a high-scoring draw between two sides who will no doubt be desperate for all three points.