Crystal Palace open their campaign up at home to 2019-20 away specialists Southampton before a difficult visit to Old Trafford to face Manchester United in their first away game of the season.
A trip to rivals Brighton & Hove Albion awaits in their fifth outing, while December sees them face three of last season's top six.
It is a difficult end to the season too - nine of their last 10 matches come against teams that finished higher than them in 2019-20, including May home games against Manchester City and Arsenal and a final-day trip to face champions Liverpool at Anfield.
© Reuters
SEPTEMBER
12: Southampton (h)
19: Manchester United (a)
26: Everton (h)
OCTOBER
3: Chelsea (a)
17: Brighton (h)
24: Fulham (a)
31: Wolves (a)
NOVEMBER
7: Leeds (h)
21: Burnley (a)
28: Newcastle (h)
© Reuters
DECEMBER
5: West Brom (a)
12: Tottenham (h)
15: West Ham (a)
19: Liverpool (h)
26: Aston Villa (a)
28: Leicester (h)
JANUARY
2: Sheffield United (h)
12: Arsenal (a)
16: Manchester City (a)
27: West Ham (h)
30: Wolves (h)
FEBRUARY
3: Newcastle (a)
6: Leeds (a)
13: Burnley (h)
20: Brighton (a)
27: Fulham (h)
© Reuters
MARCH
6: Tottenham (a)
13: West Brom (h)
20: Manchester United (h)
APRIL
3: Everton (a)
10: Chelsea (h)
17: Southampton (a)
24: Leicester (a)
© Reuters
MAY
1: Manchester City (h)
8: Sheffield United (a)
12: Aston Villa (h)
15: Arsenal (h)
23: Liverpool (a)
