The two South American nations each have one point to show from their opening two matches, with Chile losing to Uruguay and drawing with Colombia while Peru drew with Paraguay and suffered defeat to Brazil.
However, Radamel Falcao had other ideas as he struck a late equaliser in injury time to deny Chile their first victory of qualifying, with Reinaldo Rueda's men not making the start that their manager would have hoped for.
Matchday one saw Chile succumb to another late goal, with Sanchez once again on the scoresheet for Rueda's men against Uruguay, but a Luis Suarez penalty and a winner from Maxi Gomez in the dying embers saw Uruguay take the spoils in their maiden game.
Having failed to make the finals in 2018, the Roja faithful will be praying that their side can turn their fortunes around and pick up that elusive first victory on matchday three, and Chile may feel quietly confident of doing so against a Peru side who have endured an equally underwhelming start to proceedings.
Peru have also recorded one draw and one loss from their opening two matches of CONMEBOL qualification, with a double from Andre Carrillo cancelling out a brace from Paraguay's Angel Romero in that 2-2 draw in their inaugural game.
Carrillo continued his goalscoring form in Peru's next game against Brazil - the ex-Watford loanee took just five minutes to find the back of the net in that one - but a hat-trick from Neymar and a goal from Richarlison ultimately put Peru to the sword and left them still searching for their first win of qualifying.
The 2018 World Cup represented the first time since 1982 that Peru had advanced to the finals, and Ricardo Gareca will certainly be under pressure to repeat that feat once again, although the 62-year-old has achieved some notable results with Peru and is sure to have the full backing of the fans as qualification hots up.
Chile have come out on top in 12 of their last 15 meetings with Peru in all competitions, but Gareca's side have recorded back-to-back 3-0 victories in their two most recent clashes with their matchday three opponents - including last year's Copa America semi-final.
Chile World Cup Qualifying - South America form: LD
Chile form (all competitions): DLDWLD
Peru World Cup Qualifying - South America form: DL
Peru form (all competitions): WLDLDL
Chile goalkeeper Claudio Bravo has returned to the fold after missing out October's fixtures with a knee injury, and the 37-year-old is sure to start in between the sticks with Gabriel Arias dropping out.
There is also no place in the squad for Eduardo Vargas, who started up top in Chile's opening two matches against Uruguay and Colombia, with the striker recently completing a move to Atletico Mineiro.
Meanwhile, Peru stalwart Jefferson Farfan is expected to be out of action until 2021 with a serious knee injury and will play no part in November's fixtures.
However, there is a spot in the squad for Benevento forward Gianluca Lapadula, who has been called up to Peru for the first time having represented Italy at youth level.
Chile possible starting lineup:
Bravo; Isla, Diaz, Vegas, Beausejour; Vidal, Pulgar, Pinares; Orellana, Mora, Sanchez
Peru possible starting lineup:
Gallese; Advincula, Abram, Ramos, Trauco; Yotun, Tapia, Aquino; Carrillo, Ruidiaz, Flores
We say: Chile 1-2 Peru
Peru have impressed with Gareca at the helm in recent years but have not enjoyed the best of starts to their qualification campaign. Chile are also still searching for their first three points and that should make for an entertaining spectacle - with both sets of attackers capable of causing problems for their opponents' defence - but we think Peru will just do enough to nick a win.