While the Blues have picked up four points from their last two league outings, they only sit three points ahead of Manchester United.
Although Frank Lampard's side warmed up for this fixture with an impressive 2-0 victory over Liverpool in the FA Cup fifth round earlier this week, it came at a cost with more players joining a growing injury list.
Here, Sports Mole predicts how the West Londoners may line up for the encounter at Stamford Bridge.
Out: Jorginho (suspended), N'Golo Kante (hamstring), Callum Hudson-Odoi (hamstring), Tammy Abraham (ankle), Mateo Kovacic (Achilles),
Doubtful: Willian (Achilles), Christian Pulisic (muscular), Ruben Loftus-Cheek (lack of match fitness)
Having picked up his 10th yellow card of the Premier League campaign last weekend, Jorginho will now sit out the next two matches.
The Italian has been joined on the sidelines by Mateo Kovacic, who suffered a significant Achilles problem against Liverpool on Tuesday night.
Providing that Lampard opts to keep the same back four from the triumph over the league leaders, Reece James may be used further forward to replace Willian, who is also carrying an Achilles issue.
Despite coming through a second-string game earlier this week, Ruben Loftus-Cheek is unlikely to come into contention for a starting role.