While the Blues edged out Leicester City for fourth place last season, the Seagulls could only finish in 15th position in the standings.
After a relatively-successful first season in charge of Chelsea, Frank Lampard now has the task of turning his side into challengers for silverware on a regular basis.
Although they squandered the chance to win the FA Cup last month, there were positives to take from reaching the final and claiming a Champions League spot through their Premier League form.
However, having been provided with the funds to sign several world-class players, Lampard is aware that the stakes are far greater than they were during a season without being able to add to his squad.
While the club legend is still attempting to sign a new goalkeeper and defensive-minded player who can play in defence and midfield, he will feel that his squad have the firepower to outscore any opponents in the division.
Like his Chelsea counterpart, Graham Potter will feel under pressure to build on guiding Brighton to their second Premier League survival in succession.
Despite 15th spot being acceptable for his first year at the Amex Stadium, there is optimism that Brighton can challenge for a position in the top half of the table.
Facing Chelsea in their opening fixture is a tough start for Brighton, but the two teams did play out a competitive 1-1 draw in a pre-season friendly at the end of last month.
Brighton & Hove Albion form (pre-season friendlies): DD
Chelsea form (pre-season friendlies): D
Despite making good progress in his recovery from a hamstring injury, Christian Pulisic is likely to be restricted to a place on the substitutes' bench.
Given the defensive options at his disposal, Potter must choose whether to use a 4-2-3-1 formation or line up with a back three.
Preference may be given to a back four, leading to former Chelsea youngster Tariq Lamptey having to make do with a spot among the replacements.
Brighton & Hove Albion possible starting lineup:
Ryan; Veltman, White, Dunk, Burn; Propper, Bissouma; Gross, Lallana, Trossard; Maupay
Chelsea possible starting lineup:
Caballero; James, Zouma, Rudiger, Alonso; Kante, Jorginho; Havertz, Mount, Hudson-Odoi; Werner
We say: Brighton & Hove Albion 2-2 Chelsea
With Lampard having to wait to field his new-look backline, Brighton will naturally feel that they can take full advantage. However, given the options in Chelsea's attack, we feel that a thrilling draw could be played out on the South Coast.
Top betting tipOur expert tipster partners at Sporita.com are predicting under 3.5 goals in this match. Click here to find out what else they are predicting for this game and for more of their tried-and-tested football tips.Under 3.5:data
Watch the Sports Mole Football Shorts prediction for this game below: