The France midfielder has missed the last five matches with a hamstring problem, but returned to full training on Friday.
The World Cup winner would boost Frank Lampard's Blues in their quest to seal a top-four finish and Champions League qualification should he return.
Wolves boss Nuno Espirito Santo is expected to choose from an unchanged squad.
Other than aching limbs and minor niggles, the Portuguese has no new injury worries following Monday's home win against Crystal Palace.
Chelsea provisional squad: Kepa, Caballero, James, Azpilicueta, Rudiger, Zouma, Christensen, Alonso, Emerson, Tomori, Kovacic, Jorginho, Kante, Loftus-Cheek, Pedro, Willian, Hudson-Odoi, Pulisic, Mount, Abraham, Giroud.
Wolves provisional squad: Patricio, Doherty, Dendoncker, Coady, Boly, Jonny, Neves, Moutinho, Traore, Podence, Jimenez, Neto, Jota, Ruddy, Kilman, Buur, Vinagre, Saiss, Gibbs-White, Jordao.