Sarri opted against making wholesale alterations for the opening encounter with PAOK in Greece, despite the game coming before a London derby with West Ham United and back-to-back contests with Liverpool.
However, Sarri has acknowledged that the recent period has taken its toll - both mentally and physically - and has indicated that he will rest some of his first-team regulars for the game at Stamford Bridge.
At a press conference, the Italian told reporters: "I don't know. I don't think that in West Ham we didn't win because of the match in Greece. We changed a lot of players so I don't think the reason was that.
"Of course tomorrow we need to change some players because we have spent a lot of mental and physical energy in two matches against Liverpool and then after this match we have to play a match again in 62 hours so tomorrow we need to change. I don't know how many players but we need to change."
Sarri has suggested that Ruben Loftus-Cheek should be available to start the game in West London after recovering from injury.