Les Phoceens' opening fixture against Saint-Etienne was postponed due to a coronavirus outbreak, while Brest were thumped 4-0 by Nimes on matchday one.
Just short of six months since their most recent league outing, a 2-2 draw with Amiens, Marseille will be keen to mark their return to action with all three points on Sunday.
Andre Villas-Boas's men finished runners-up to Paris Saint-Germain in last season's shortened Ligue 1 campaign, albeit 12 points behind the runaway champions.
A season of Champions League football awaits Marseille, but the more immediate priority for Villas-Boas will be to string together some wins in order to put some pressure on PSG.
The Parisians reached the Champions League final and are not in league action for another couple of weeks, so Les Phoceens have a chance to open up a gap at the summit before then.
Marseille lost just one of their last 17 Ligue 1 games in 2019-20 - against Nantes in February - and won all but four of those.
They are also unbeaten in their last eight away top-flight matches, which is the best current run and their longest run since October 2015-March 2016 (11).
Getting off to a winning start is imperative to Villas-Boas, and a trip to Brest may just be the best way to ease themselves into the new campaign.
Brest have now failed to keep a clean sheet in 10 of their last 11 Ligue 1 games - the only exception being a goalless draw with Rennes in February.
Olivier Dall'Oglio will undoubtedly be after a response from his side, who ended last season with back-to-back losses without finding the net.
However, Brest have lost just one of their 10 home games against Marseille - albeit in the most recent clash in December 2012 - and will be looking to pull off an upset here.
Brest Ligue 1 form: L
Marseille pre-season form: WWLL
Marseille's opening game of the season was called off due to a high number of positive Covid-19 tests and the club announced some fresh cases in midweek.
In terms of the hosts, defender Christophe Herelle is a confirmed absentee as he recovers from coronavirus.
Brest possible starting lineup:
Larsonneur; Pierre-Gabriel, M'Bock, Duverne, Perraud; Honorat, Diallo, Battocchio, Tavares; Cardona; Charbonnier
Marseille possible starting lineup:
Pele; Amavi, Kamara, Caleta-Carr, Sakai; Sanson, Strootman, Khaoui; Radonjic, Benedetto, Thauvin
We say: Brest 0-2 Marseille
Lyon and Marseille are realistically the only sides that can challenge PSG for the title this term. If that is to be the case, Villas-Boas's men simply cannot afford to slip up in games such as this one, and we are not expecting that to be the case.