Lucien Favre's side were knocked out of the Champions League by Paris Saint-Germain on Wednesday night but cannot afford to dwell on the defeat as they prepare to resume Bundesliga action.
Saturday's clash at Signal Iduna Park will be played behind closed doors due to the coronavirus outbreak, meaning that the players will have to create the atmosphere on the field.
Dortmund's 2-0 defeat to PSG in the second leg of their last-16 Champions League clash on Wednesday night saw them exit the competition 3-2 on aggregate.
Favre's team have won each of their last four in the Bundesliga, though, including an impressive 2-1 victory away to Borussia Monchengladbach last weekend.
BVB are currently second in Germany's top flight, four points off leaders Bayern Munich. RB Leipzig in third are just five points off the summit, meanwhile, as the campaign prepares to enter its latter stages.
The reverse match earlier this season ended in a goalless draw, but Schalke actually recorded a 4-2 victory over Dortmund when the pair met in the corresponding clash during the 2018-19 campaign.
Schalke might be the fresher of the two teams due to Dortmund's European involvement, but David Wagner's side will certainly enter the match in the poorer form.
Indeed, the Royal Blues are without a victory in their last six games in all competitions, losing three of their last four in the process, while they have not won in the Bundesliga since January 17.
They did pick up a point at home to Hoffenheim last weekend and remain sixth in the table but are now 10 points behind fifth-placed Bayer Leverkusen with not too much football left to play.
Schalke have only lost one of their last eight Bundesliga games against Dortmund, though, and will be determined to return to winning ways against their rivals this weekend.
Dortmund Bundesliga form: WLWWWW
Dortmund form (all competitions): WWWWWL
Schalke Bundesliga form: DDDLLD
Schalke form (all competitions): DDLLLD
As for Schalke, Wagner has a lengthy injury list to contend with; Omar Mascarell, Daniel Caligiuri, Benjamin Stambouli, Salif Sane and Ozan Kabak are all out, while Suat Serdar and Juan Miranda are both doubts.
Dortmund possible starting lineup:
Burki; Hummels, Zagadou, Piszczek; Guerreiro, Witsel, Can, Hakimi; Sancho, Haaland, Brandt
Schalke possible starting lineup:
Schubert; Kenny, Oczipka, Todibo, Nastasic, Becker; Raman, Schopf, McKennie, Matondo; Burgstaller
We say: Dortmund 2-0 Schalke
Dortmund's recent record against Schalke is surprisingly poor, but the visitors are not in good form at the moment, and we expect BVB to put a much-needed three points on the board here.