Manuel Pellegrini's side recorded a 1-0 victory over Alaves in their season opener last weekend, while Valladolid shared the points with Real Sociedad on home soil.
There is no getting away from the fact that Betis were disappointing in Spain's top flight last season, finishing 15th in the table, only five points above the relegation zone.
Pellegrini was appointed head coach of the Seville outfit in July, though, and the Chilean got his tenure off to a perfect start last weekend courtesy of a late goal from Cristian Tello, which secured a 1-0 victory over Alaves.
The Green and Whites will be eyeing another positive result ahead of their next game at home to Real Madrid on September 26, but they have lost their last two games against Valladolid, including a 2-1 defeat in the corresponding match during the 2019-20 campaign.
Valladolid, meanwhile, finished 13th in La Liga last season, which actually represented their best placing in Spain's top flight for almost 20 years.
Sergio Gonzalez's side appear to be heading firmly in the right direction, and they started their 2020-21 campaign with a point at home to Sociedad last weekend.
Valladolid have managed to bring a number of new players to the club this summer, but there has also been a major outgoing, with highly-rated centre-back Mohammed Salisu joining Southampton.
Pucela were 10 points off the top half of La Liga last season, and there is no question that the supporters will be looking for their side to push towards the top 10 during the current campaign.
Real Betis La Liga form: W
Real Valladolid La Liga form: D
Real Betis possible starting lineup:
Bravo; Emerson, Mandi, Bartra, Moreno; Rodriguez, Carvalho; Joaquin, Canales, Fekir; Iglesias
Real Valladolid possible starting lineup:
Jimenez; Moyano, Gonzalez, Fernandez, Nacho; Plano, Emeterio, Michel, Orellana; Guardiola, Weissman
We say: Real Betis 1-1 Real Valladolid
Both sides picked up good results on the opening weekend, and we are struggling to separate the two teams on this occasion. Betis underachieved last term and should push higher up the table in 2020-21, but Valladolid have developed into a strong side and are capable of claiming a point here.