The reigning champions put eight unanswered goals past Schalke 04 in their season opener last weekend, while Hoffenheim also started with a positive result, running out 3-2 winners at Koln.
Hoffenheim, as mentioned, made a positive start to their 2020-21 Bundesliga campaign last weekend, recording a 3-2 success at Koln, with Croatian forward Andrej Kramaric scoring a brilliant hat-trick.
Die Kraichgauer finished sixth in the Bundesliga last term and will therefore compete in the group stages of this season's Europa League.
There was a change of manager at the end of last season, though, with Sebastian Hoeness leaving his role with Bayern's reserve side to take on the position.
The 38-year-old will be determined to upset his former employers on Sunday afternoon, but Bayern ran out 6-0 winners when they travelled to Hoffenheim in the corresponding fixture last term.
Bayern, as mentioned, started their title defence with a stunning 8-0 win over Schalke at the Allianz Arena last weekend, with Serge Gnabry netting a hat-trick for the champions.
Bayern again proved to be far too strong for the rest of the Bundesliga last season, picking up 82 points from their 34 matches to finish 13 points clear of second-placed Borussia Dortmund.
The Munich giants have now won the German title in each of the last eight seasons, but the 2019-20 campaign proved to be particularly special as they also won the German Cup and Champions League.
It does appear that Der FCB will be the team to beat in the European Cup again this term, with the addition of Leroy Sane from Manchester City making them even stronger in the final third of the field.
Hoffenheim Bundesliga form: W
Bayern Munich Bundesliga form: W
Bayern Munich form (all competitions): WW
Hoeness's side did not pick up any fresh problems against Koln last weekend, though, and it would therefore not be a surprise to see the same starting XI sent onto the field.
David Alaba should start alongside Niklas Sule in the middle of the defence, while there is likely to be a spot for Alphonso Davies at left-back despite the fact that Lucas Hernandez has started the first two matches of the season.
Hoffenheim possible starting lineup:
Baumann; Nuhu, Vogt, Bicakcic; Akpoguma, Geiger, Samassekou, Kaderabek; Dabour, Kramaric, Baumgartner
Bayern Munich possible starting lineup:
Neuer; Pavard, Sule, Alaba, Davies; Kimmich, Goretzka; Gnabry, Muller, Sane; Lewandowski
We say: Hoffenheim 1-3 Bayern Munich
Hoffenheim are certainly capable of making it a very difficult 90 minutes for Bayern, but it is so difficult to look past the champions due to their incredible attacking capabilities. We expect Flick's side to move onto six points in the league with a relatively routine victory this weekend.