The recent upturn in results has put the Catalan giants in a position where victory at the San Mames Stadium will move the club into third position in the standings.
However, with a number of long-term injuries to contend with, Ronald Koeman will likely make changes for the club's second game in 72 hours.
Here, Sports Mole predicts how Barcelona could line up for the game against opponents who have just appointed Marcelino as their new manager.
While positives and negatives were taken from the 1-0 victory at bottom-of-the-table side Huesca on Sunday, it is unlikely to influence Koeman's thinking regarding his next XI.
Ousmane Dembele completed 90 minutes for just the third time in two months at the weekend, something which may relegate the Frenchman to the substitutes' bench.
Philippe Coutinho will play no part in this match after it was revealed that he required surgery on a knee injury.