Diego Simeone's side are currently second in Group A with three points to show from their two matches in the section, while Lokomotiv sit third with one point from their opening two fixtures.
Lokomotiv opened their Champions League campaign with an impressive point away to Red Bull Salzburg before suffering a 2-1 defeat to Bayern Munich last week, with a total of one point leaving them third in the section.
It was always going to be a huge ask for the Russian side to qualify from this group considering the strength of the opposition, but they have performed impressively in their two fixtures thus far.
This is the third year in a row that Lokomotiv have been in the group stage of the Champions League, but they have finished bottom of their section in the last two seasons. Parovozy have actually lost 12 of their last 15 matches in the group stage of the Champions League, while they have been victorious in just two of their last 16 European fixtures, which is an indication of the size of their task.
Marko Nikolic's side will enter this match off the back of a 2-1 loss to Sochi in the league on Saturday, and they are currently sixth in their domestic table with 21 points to show from 13 matches.
Atletico, meanwhile, opened their European campaign with a heavy 4-0 loss to Bayern in Germany but managed to recover last week, recording a 3-2 win over Salzburg to put an important three points on the board.
The capital side were 2-1 behind in the early stages of the second half at the Wanda Metropolitano but Felix scored twice to secure the victory against the Austrian club.
Atletico are also going well in Spain's top flight, winning each of their last three, including a 3-1 success away to Osasuna on Saturday to move into third, two points behind leaders Real Madrid with a game in hand.
The Red and Whites have reached at least the quarter-finals in five of their last seven Champions League campaigns, including last season, when they were knocked out by RB Leipzig courtesy of a 2-1 defeat.
Interestingly, Atletico have never lost in Russia, winning five of their seven matches, including a 2-0 victory away to Lokomotiv last season and a 5-1 victory against the same opponents in Moscow during the 2017-18 Europa League.
Lokomotiv Moscow Champions League form: LLLLDL
Lokomotiv Moscow form (all competitions): WWDLLL
Atletico Madrid Champions League form: WWWLLW
Atletico Madrid form (all competitions): DWLWWW
Lokomotiv will again be without the services of Mikhail Lysov, but the Russian outfit are otherwise expected to be in good shape in terms of injuries, and it would not be a surprise to see the same side that took to the field against Bayern in the team's last Champions League fixture.
Luis Suarez was not involved in Saturday's win over Osasuna, but the Uruguay international will return to the starting XI for this match, with the experienced striker set to join Felix in the final third.
Lokomotiv Moscow possible starting lineup:
Guilherme; Rybus, Murilo, Corluka, Zhivoglyadov; Krychowiak, Kulikov, Ignatjev; Miranchuk, Ze Luis, Smolov
Atletico Madrid possible starting lineup:
Oblak; Trippier, Savic, Gimenez, Lodi; Correa, Llorente, Torreira, Koke; Felix, Suarez
We say: Lokomotiv Moscow 1-2 Atletico Madrid
Atletico have now won their last three matches in all competitions and have shown plenty of quality in the early stages of the campaign. Lokomotiv are capable of making it a very uncomfortable 90 minutes, but we fancy Simeone's side to pick up all three points on Tuesday night.