Juventus head into Wednesday's showdown at Wanda Metropolitano having been held to a goalless draw by Fiorentina at the weekend.
Nevertheless, the Argentine would have been disappointed to see his side lose out 2-0 to Real Sociedad at the weekend, especially on the back of needing to overturn a two-goal deficit to get the better of Eibar in front of their own supporters.
Atletico still remain in second position in the table, just a point adrift of Sevilla, but there is little doubt that they must make improvements in order to register a positive result against Juventus.
However, Juventus will arrive in Spain also aware that they still need to go through a few more gears in order to repeat their success of previous seasons.
A return of seven points from their first three Serie A fixtures is a respectable return, especially when considering the dramatic showdown with Napoli at the end of August.
Nevertheless, failing to find the back of the net at Fiorentina and a mounting injury list has only given Maurizio Sarri more food for thought ahead of facing the La Liga giants.
Sarri will also want to see more from Cristiano Ronaldo, who has contributed just one goal this season ahead of his return to Madrid, a city where he spent nine hugely successful years with Real.
Atletico Madrid form: WWWL
Juventus form: WWD
Goalkeeper Jan Oblak is regarded as a doubt for Atletico having been withdrawn from the game with Real Sociedad due to a head injury.
The triple blow leaves Sarri with issues at right-back, with Juan Cuadrado potentially being used as a make-shift replacement.
Atletico Madrid possible starting lineup: Adan; Trippier, Savic, Gimenez, Lodi; Vitolo, Koke, Saul, Lemar; Felix, Costa
Juventus possible starting lineup: Szczesny; Cuadrado, Bonucci, De Ligt, Sandro; Bernardeschi, Rabiot, Khedira, Matuidi; Ronaldo, Higuain
We say: Atletico Madrid 1-1 Juventus
With both clubs struggling to put together consistent performances over the opening weeks of the season, we feel that they may cancel each other out in Madrid, placing an onus on avoiding defeat on Matchday One of this competition.
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