Meanwhile, St Mirren are unbeaten in their last six matches in all competitions, winning their last two games by a 1-0 scoreline.
St Mirren have been grateful to use the Scottish League Cup as an escape from their poor league form, with the Saints sitting 11th in the Scottish Premiership, one place above rock-bottom Hamilton Academical.
The Saints now focus on Scottish League Cup action after finishing top of Group G and winning all four matches – two of which were won on penalties against Queen of the South and Greenock Morton.
St Mirren, who won the competition in the 2012-13 season, will qualify for the quarter-finals if they defeat Aberdeen, whom they have not beaten in any of their previous four meetings.
Aberdeen missed the chance to move a point behind Celtic in the Scottish Premiership after drawing 1-1 with Hamilton Academical on Wednesday night.
The Dons now turn their attention to the Scottish League Cup, a competition where they have reached the quarter-final stage in each of the last four seasons, including losing two finals to Celtic.
Manager Derek McInnes, who won his first and only trophy with Aberdeen in this competition back in the 2013-14 campaign, will be hoping that his team can bounce back from a disappointing week with victory over a St Mirren side who they have beaten in three of their last four meetings.
St Mirren Scottish League Cup form: WWWW
St Mirren form (all competitions): WWDWWW
Aberdeen form (all competitions): WDLWLD
St Mirren possible starting lineup:
Alnwick; Fraser, McCarthy, Foley; Morais, Erhanon, McGrath, MacPherson, Tait; Erwin, Obika
Aberdeen possible starting lineup:
Lewis; Hoban, Taylor, Considine; Logan, Campbell, Ojo, Leigh; Hedges, Edmondson; Cosgrove
We say: St Mirren 0-1 Aberdeen
St Mirren are unbeaten in their last six matches in all competitions, although their last defeat came against an Aberdeen side who will be keen to shore up their backline after conceding 12 goals in their last six games. A tight encounter is expected with Aberdeen likely to sneak into the last eight.