The Liverpudlian, who claims that he is "ready to conquer the world", will face Congolese boxer Ilunga Makabu at Goodison Park on Sunday, May 29.
"I'm over the moon to get this opportunity," Bellew told reporters.
"This is the defining fight and night of my career. The experience has been passed, I've done it all now, British, Commonwealth, European - beaten fringe contenders, former world champions - I'm ready to conquer the world."
The 33-year-old's professional record is 26-2-1 with 16 knockouts, while Makabu has lost one of his 20 professional fights with 18 of his 19 wins coming by way of knockout.