Antetokounmpo, the reigning MVP and the league's second-leading scorer with an average of 30.5 points per game entering this one, had missed the Bucks' past two games.
He played only 27 minutes and sat out the final five as Milwaukee pulled away from the mid-table Bulls to strengthen their clear lead at the top of the Eastern Conference.
The Wizards were 13th to Miami's second in the East before the game, and were missing All-Star shooting guard Bradley Beal and five other key players.
But in their absence Jordan McRae led the way with a season-high 29 points, Garrison Mathews had a career-high 28, and Ian Mahinmi added a career-best 25.
Miami, who had a five-game winning streak broken, were led by Jimmy Butler with 27 points.
Derrick Rose poured in 20 points for the Pistons, who have lost seven straight against Utah.
In other games, the Minnesota Timberwolves beat the visiting Brooklyn Nets 122-115 in overtime, the Atlanta Hawks were 101-93 victors at the Orlando Magic and the Phoenix Suns won 122-116 at the Portland Trail Blazers.